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Characteristics associated with increased likelihood of necrotizing infection
| Clinical parameters | Laboratory parameters |
|---|---|
| Pain out proportion to examination | Serum sodium <135 mmmol/L |
| Bullae | White blood cell count >15,400 cell/mm3 |
| Tenderness beyond area of erythema | Renal failure |
| Crepitus | Progressive lactic acidosis |
| Cutaneous anesthesia | |
| Cellulitis refractory to antibiotic therapy | |
| Rapid progression of cellulitis | |
| Dusky appearance of skin | |
| Systemic toxicity |
