Fig. 1. Identification of domoic acid biosynthetic genes from transcriptomic and genomic data.
(A) Structure of DA (1) and its proposed biosynthetic building blocks (14, 15). (B) Ten most up-regulated P. multiseries transcripts under previously reported DA-induction conditions (17). Differential expression changes are each shown with reference to the Pco2 conditions listed across the top of the heatmap, with phosphate concentrations held constant. (C) DA biosynthesis (dab) gene cluster in the P. multiseries genome.