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. 2018 Nov 18;2018:7816923. doi: 10.1155/2018/7816923

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Copyright © 2018 An-Na Won et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of STE on the productions of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. (a) Effects of STE on the cell viability. (b) Effects of STE on LPS-induced NO production. (c) Effects of STE on LPS-induced PGE₂ production. (d) Effects of STE on the induction of iNOS and COX-2 by LPS. RAW 264.7 macrophages were pretreated with different concentrations of STE (10, 100, or 300 μg/mL) for 1 h and subsequently exposed to LPS (1 μg/mL) for 24 h, and then protein expressions of iNOS and COX-2 were assessed by western blot. Statistical significance was determined versus vehicle-treated control group (^###P < 0.001) or LPS-treated group (^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001).