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. 2018 Nov 18;2018:7816923. doi: 10.1155/2018/7816923

Figure 5.

Figure 5

Induction of Nrf2/HO-1 signaling pathway by STE. (a) Immunofluorescence images of the nuclear translocation of Nrf2 induced by STE. RAW 264.7 cells were treated with STE (300 μg/mL) for 3 h. (b) Induction of HO-1 by STE. RAW 264.7 cells were treated with various concentrations of STE (10, 100, or 300 μg/mL) for 18 h, lysed, and western blotted. (Significant vs. vehicle-treated control, ∗p < 0.05 and ∗∗p < 0.01). (c) Blocking of the NO inhibitory effect of STE on LPS-induced NO production by SnPP. RAW 264.7 cells were pretreated with STE (300 μg/mL) for 1 h in the presence or absence of SnPP (50 μM, 30 min) and then stimulated with LPS (1 μg/mL) for 18 h. (∗∗∗p < 0.001).