Table 3.

Retrospective studies of statin use in humans and the risk of developing tuberculosis.

Author	Year	Method	Patients	Conclusions
Kang et al.	2014	Retrospective cohort study	840,894 newly diagnosed type 2 DM patients aged 20-99 years who were newly treated with antidiabetic drugs	Statin use in newly diagnosed type 2 diabetics was not associated with protection against or a higher risk of developing tuberculosis
Lee et al.	2015	Retrospective cohort study	13,981 patients with type 2 diabetes aged more than 65 years	After adjusting for age, sex, other comorbidities, and medications, statin users had a lower independent association, with a risk ratio of 0.76 (95% CI, 0.60-0.97)
Lai et al.	2016	Retrospective nested case-control study	8098 new TB cases and 809,800 control patients	Statin users had a decreased risk of active tuberculosis. Chronic use of statins (more than 90 days) was associated with the lowest risk (RR 0.62; 95% CI 0.53-0.72)
Su et al.	2017	Retrospective nested case-control study	102,424 statin users, 202,718 patients aged 20 years or older, and 202,718 matched subjects	Statin use is an independent protective factor for tuberculosis development. There is a dose-dependent association between statin use and risk of active tuberculosis