Table 3.
Meta-analysis of the association between ERCC2 rs13181 polymorphism and chemotherapy in objective response rate and overall survival for gastric cancer patients.
| Genetic comparisons | Subgroup analysis | No. of studies | Test of association | Model | Test of heterogeneity | P Egger | |||
|---|---|---|---|---|---|---|---|---|---|
| OR/HR (95% CI) | Z | P | P | I 2 (%) | |||||
| Objective response rate (OR) | |||||||||
| CC vs. AA | Total ethnicity | 7 | 1.01 (0.61–1.68) | 0.04 | 0.968 | R | 0.003 | 69.30 | 0.892 |
| Caucasian | 2 | 1.16 (0.26–5.27) | 0.20 | 0.845 | R | 0.004 | 88.20 | ||
| Asian | 5 | 1.00 (0.58–1.74) | 0.00 | 0.997 | R | 0.047 | 58.50 | ||
| AC vs. AA | Total ethnicity | 7 | 1.06 (0.83–1.37) | 0.47 | 0.641 | R | 0.143 | 37.40 | 0.517 |
| Caucasian | 2 | 1.06 (0.70–1.61) | 0.28 | 0.783 | R | 0.290 | 10.70 | ||
| Asian | 5 | 1.04 (0.74–1.46) | 0.25 | 0.806 | R | 0.077 | 52.60 | ||
| CC + AC vs. AA | Total ethnicity | 10 | 1.07 (0.84–1.36) | 0.52 | 0.600 | R | 0.017 | 55.40 | 0.661 |
| Caucasian | 2 | 1.07 (0.48–2.39) | 0.17 | 0.866 | R | 0.040 | 76.30 | ||
| Asian | 8 | 1.08 (0.83–1.41) | 0.58 | 0.562 | R | 0.037 | 53.20 | ||
| CC vs. AA + AC | Total ethnicity | 7 | 0.98 (0.65–1.46) | 0.12 | 0.907 | R | 0.031 | 56.70 | 0.760 |
| Caucasian | 2 | 1.06 (0.31–3.66) | 0.09 | 0.925 | R | 0.006 | 86.70 | ||
| Asian | 5 | 1.02 (0.70–1.50) | 0.12 | 0.907 | F | 0.270 | 22.60 | ||
|
| |||||||||
| Overall survival (HR) | |||||||||
| CC vs. AA | Asian | 5 | 0.99 (0.72–1.36) | 0.09 | 0.928 | F | 0.185 | 35.4 | 0.739 |
| AC vs. AA | Asian | 5 | 1.01 (0.78–1.30) | 0.07 | 0.947 | F | 0.468 | 0 | 0.651 |
| CC + AC vs. AA | Asian | 6 | 1.28 (0.85–1.91) | 1.18 | 0.238 | R | 0.073 | 50.4 | 0.814 |
OR: odds ratio; HR: hazard ratio; CI: confidence interval; vs.: versus; F: fixed effect model; R: random effect model.