Table 4.
Meta-analysis of the association between ERCC2 rs1799793 polymorphism and chemotherapy in objective response rate and overall survival for gastric cancer patients.
| Genetic comparisons | Subgroup analysis | No. of studies | Test of association | Model | Test of heterogeneity | P Egger | |||
|---|---|---|---|---|---|---|---|---|---|
| OR/HR (95% CI) | Z | P | P | I 2 (%) | |||||
| Objective response rate (ORR) | |||||||||
| AA vs. GG | Total ethnicity | 8 | 1.17 (0.70–1.95) | 0.59 | 0.556 | R | 0.002 | 69.2 | 0.348 |
| Caucasian | 2 | 1.70 (0.71–4.05) | 1.19 | 0.234 | R | 0.080 | 67.4 | ||
| Asian | 6 | 0.98 (0.48–1.98) | 0.06 | 0.950 | R | 0.002 | 74.1 | ||
| GA vs. GG | Total ethnicity | 9 | 0.94 (0.69–1.27) | 0.41 | 0.679 | R | 0.012 | 59.1 | 0.259 |
| Caucasian | 2 | 0.88 (0.23–3.38) | 0.19 | 0.805 | R | 0.003 | 89.0 | ||
| Asian | 7 | 1.01 (0.82–1.24) | 0.06 | 0.955 | F | 0.299 | 17.2 | ||
| AA + GA vs. GG | Total ethnicity | 10 | 1.12 (0.85–1.46) | 0.79 | 0.429 | R | 0.001 | 68.9 | 0.661 |
| Caucasian | 2 | 1.15 (0.39–3.42) | 0.26 | 0.797 | R | 0.009 | 85.5 | ||
| Asian | 8 | 1.13 (0.86–1.49) | 0.87 | 0.384 | R | 0.006 | 64.8 | ||
| AA vs. GG + GA | Total ethnicity | 8 | 1.24 (0.81–1.92) | 0.98 | 0.325 | R | 0.009 | 62.6 | 0.053 |
| Caucasian | 2 | 1.79 (1.24–2.57) | 3.13 | 0.002 | F | 0.794 | 0 | ||
| Asian | 6 | 1.02 (0.54–1.90) | 0.05 | 0.962 | R | 0.006 | 69.2 | ||
|
| |||||||||
| Overall survival (HR) | |||||||||
| GA vs. GG | Asian | 8 | 1.20 (0.96–1.51) | 1.61 | 0.108 | F | 0.577 | 0 | 0.900 |
| AA vs. GG | Asian | 6 | 1.77 (1.20–2.60) | 2.89 | 0.004 | F | 0.227 | 27.7 | 0.959 |
| GA + AA vs. GG | Asian | 4 | 1.62 (1.26–2.09) | 3.76 | <0.001 | F | 0.479 | 0 | 0.032 |
OR: odds ratio; HR: hazard ratio; CI: confidence interval; vs.: versus; F: fixed effect model; R: random effect model.