. 2018 Nov 15;96(12):5035–5051. doi: 10.1093/jas/sky377

Table 6.

Extra-intestinal catabolism of arginine via arginase and nonarginase pathways in pigs supplemented with or without L-arginine for 13 wk

Supplemental dose of Arg (mg/(kg body weight·d)	Extra-intestinal catabolism of Arg to form its metabolites via nonarginase pathways¹				Extra-intestinal catabolism of Arg via arginase²
Supplemental dose of Arg (mg/(kg body weight·d)	Homoarginine	Creatine	NOx	Agmatine	Extra-intestinal catabolism of Arg via arginase²
			mg Arg·kg BW⁻¹·d⁻¹
0	0.088 ± 0.004^c	83.9 ± 3.7^c	2.86 ± 0.17^c	0.036 ± 0.003^c	278 ± 5.6^c
315	0.138 ± 0.005^b	96.7 ± 4.3^b	4.35 ± 0.22^b	0.047 ± 0.003^b	453 ± 8.1^b
630	0.194 ± 0.008^a	109 ± 4.9^a	5.67 ± 0.31^a	0.060 ± 0.004^a	628 ± 11^a

^a–cWithin a column for each species, means sharing different superscript letters differ (P < 0.05).

Adapted from Wu et al. (2016). Values are means ± SEM, n = 12 pigs (121 d of age; 6 males and 6 females) per dietary group.

¹Homoarginine, creatine, NOx (nitrite plus nitrate), and agmatine were produced from Arg via nonarginase pathways.

²These values are calculated as the rates of Arg catabolism via arginase plus nonarginase pathways minus the rates of Arg catabolism via the nonarginase pathway. The values of extra-intestinal Arg catabolism via the arginase pathway do not include proteins released by extra-intestinal tissues.