Genetic analysis of pregnancy tissue is not routinely recommended but it could be performed for explanatory purposes (Hogge et al., 2003; Bernardi et al., 2012; Foyouzi et al., 2012; van den Berg et al., 2012).	Conditional ⊕⊕○○
For genetic analysis of the pregnancy tissue, array-based comparative genomic hybridization (array-CGH) is recommended based on a reduced maternal contamination effect (Robberecht et al., 2009).	Strong ⊕⊕○○
Parental karyotyping is not routinely recommended in couples with RPL. It could be carried out after individual assessment of risk (Franssen et al., 2006; Barber et al., 2010) (Franssen et al., 2005; Sugiura-Ogasawara et al., 2008; Flynn et al., 2014).	Conditional ⊕⊕○○