Table I.
Summary of peer-reveiwed papers published from January 2000 to June 2017 included in the review of ART in sub-Saharan Africa: study design, setting, size and outcomes reported.
| Region/country | References | Study design and quality | Setting | Study population/Sample size | Outcomes reported | ||
|---|---|---|---|---|---|---|---|
| Availability | Effectiveness | Safety | |||||
| Global | Dyer et al. (2016) | Registry report (H) | NA | Data from Cameroon, Mali, South Africa | x | x | x |
| Ory et al. (2016) | Survey (H) | Na | Data from Cameroon, Kenya, Mali, Nigeria, Senegal, South Africa | x | x | ||
| Sub-Saharan Africa | Gerrits and Shaw (2010) | Systematic reviewa (L) | NA | 68 publications | x | x | x |
| Giwa-Osagie (2002) | Survey (L) | NA | ART practitioners from 10 countries. | x | x | x | |
| Kenya | Murage et al. (2011) | Cross-sectional (M) | NA | 188 Obstetricians and Gynaecologists | x | x | |
| Noreh et al. (2009) | Retrospective Cohort (L) | Private ART centre | 362 initiated fresh IVF cycles | x | x | x | |
| 430 fresh and frozen ET | |||||||
| Nigeria | Adegbola and Akindele (2013) | Retrospective Cohort (L) | University hospital | 2724 women attending GOC including 730 infertile couples | x | ||
| Adenike et al. (2014) | Cross-sectional (H) | University hospitals (public) | 250 women attending GOC | x | |||
| Adesiyun (2011) | Letter to Editor (L) | University hospital | 23 couples in 8 years | x | x | x | |
| Adeyemi et al. (2009) | Retrospective Cohort (L) | University hospital | 208 women attending GOC | x | |||
| Ajayi and Dibosa-Osadolor (2013) | Cross-sectional (M) | Conference | 102 obstetricians and gynaecologists attending academic meeting | x | x | ||
| Ezechi et al. (2008) | Case–control (H) | Private hospital | 52 ART pregnancies in 48 women | x | x | x | |
| 2160 pregnancies in non-infertile women | |||||||
| Jegede and Fayemiwo (2010) | Cross-sectional (M) | Community setting | 23 informants from diverse background incl two health care professionals | x | x | ||
| Melie (2003) | Cross-sectional (M) | Private ART centre | 452 aspirations with ≥ one oocyte | x | x | ||
| 421 fresh non-donor ET | |||||||
| Menuba et al. (2014) | Prospective Cohort (M) | University hospital | 1983 women attending GOC including 218 infertile couples | x | |||
| Okohue et al. (2009) | Prospective Cohort (M) | Private ART centres (n = 2) | 298 women < 36 y | x | x | x | |
| 276 fresh non-donor ET | |||||||
| Okohue (2010a) | Case report (M) | Private ART centre | 5 women with ectopic pregnancies after ART | x | |||
| Okohue (2010b) | Cross-sectional (M) | Private ART centre | 54 women undergoing ART | x | x | ||
| Okohue et al. (2013) | Retrospective Cohort (M) | Private ART centre | 72 women < 36 y | x | x | ||
| 76 embryo transfers | |||||||
| Okwelogu et al. (2012) | Cross-sectional (M) | Public hospitals | 500 women attending infertility clinics | x | x | ||
| Oloyede et al. (2012) | Retrospective cohort (H) | Private ART centre | 55 intrauterine ART pregnancies | x | x | ||
| Orhue et al. (2012) | Retrospective Cohort (M) | University hospital | 600 fresh non-donor ART cycles | x | x | x | |
| 504 fresh embryo transfers | |||||||
| Rwanda | Dhont et al. (2011) | Prospective Cohort (H) | University hospital (public) | 312 Infertile women and partners attending infertility clinicb | x | ||
| South Africa | Abels (2007) | Randomized controlled trial (M) | University hospital (public) | 85 women | x | x | |
| 45 GIFT cycles with ≥ three oocytes, 44 IUI cycles | |||||||
| Bosman et al. (2015) | Case-control (L) | Private ART centre | 82 couples with female partners < 38 y and ≥5 oocytes/aspiration | x | x | ||
| 82 ETs after IVF | |||||||
| Dyer and Kruger (2012) | Registry report (M) | Private and public-academic ART Centres | 12 ART centres | x | x | x | |
| 4512 aspirations | |||||||
| 3872 embryo transfers | |||||||
| Dyer et al. (2013) | Cross-sectional (H) | University hospital (public) | 135 couples | x | |||
| 135 initiated cycles | |||||||
| Raja and Franken (2006) | Prospective Cohort (H) | Private ART centre | 39 couples requiring ICSI. No. cycles not specified. | x | |||
| Windt et al. (2002) | Retrospective Cohort (M) | Not specified | 142 aspiration cycles with ≥ one oocytes; fertilisation by ICSI with testicular extracted sperm | x | |||
ET, embryo transfer; GIFT, gamete intrafallopian transfer; GOC, gynaecology outpatient clinic; H, high quality; low quality; M, medium quality; No., number.
aNot adherent to PRISMA guidelines.
bTemporary infertility clinic in a research setting.