Table I.
An association analysis of the three SNPs with serum testosterone levels in two Japanese male cohorts.
| SNP | Chr | Position | Gene | Location | Effect/other | Cohort 1 (N = 901) | Cohort 2 (N = 786) | Combined | Heterogeneity | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EAF | βSTD (SE) | P | EAF | βSTD (SE) | P | βSTD (SE) [model]a | Pmeta | Var (%)b | Phetero | I2 (%) | ||||||
| Testosterone | ||||||||||||||||
| rs2075230 | 17 | 7487108 | SHBG | Upst. | A/G | 0.565 | 0.18 (0.046) | 1.3 × 10−4 | 0.556 | 0.12 (0.049) | 1.4 × 10−2 | 0.15 (0.033) [F] | 7.2 × 10−6 | 1.1 | 0.39 | 0.0 |
| rs6259 | 17 | 7536527 | SHBG | Exon | A/G | 0.107 | 0.073 (0.075) | 0.33 | 0.116 | 0.26 (0.072) | 3.8 × 10−4 | 0.17 (0.092) [R] | 0.071 | 0.5 | 0.076 | 68.1 |
| rs727428 | 17 | 7537792 | SHBG | Dwnst. | G/A | 0.396 | 0.11 (0.048) | 0.019 | 0.366 | 0.050 (0.049) | 0.31 | 0.082 (0.034) [F] | 0.017 | 0.3 | 0.36 | 0.0 |
Data are shown as the estimated standardized linear regression statistic βSTD, SE and P value with adjustments for age and BMI. Testosterone and sex hormone-binding globulin (SHBG) were processed using natural log-transformed variables. Bold numbers indicate significance (P value < 0.0083) after adjusting for multiple testing. SNP, single nucleotide polymorphisms; Chr, chromosome; EAF, effect allele frequency; βSTD, standardized regression coefficient; Phetero, P value for heterogeneity; Upst., upstream; Dwnst., downstream.
aThe β-coefficient and its SE were summarized using an inverse variance-weighted meta-analysis, under fixed-effects model [F] or the DerSimonian and Laird method under random-effects model [R].
bPercentage of phenotypic variance (log-transformed) explained by SNP.