Table 3.
Relations Between Hormones and Carotid IMT, Adventitial Diameter, and Plaque
| Mean IMT |
IAD |
Plaque Presence |
||||
|---|---|---|---|---|---|---|
| β(SE) |
β(SE) |
OR (95% CI) |
||||
| Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | |
| E1 | 0.008 (0.009) | 0.01 (0.009) | 0.02 (0.05) | –0.003 (0.05) | 1.14 (0.82–1.59) | 1.31 (0.88–1.95) |
| E2 | –0.0003 (0.004) | 0.001 (0.004) | –0.04 (0.02)a | –0.06 (0.02)b | 1.01 (0.88–1.16) | 1.10 (0.93–1.32) |
| T | 0.016 (0.018) | 0.007 (0.016) | –0.006 (0.10) | –0.06 (0.10) | 0.84 (0.43–1.64) | 0.91 (0.44–1.89) |
| SHBG | –0.01 (0.009) | 0.01 (0.01) | 0.02 (0.05) | 0.15 (0.06)b | 1.27 (0.89–1.79) | 1.84 (1.16–2.91)c |
| FTd | 0.02 (0.01) | –0.013 (0.01) | –0.03 (0.07) | –0.19 (0.08)b | 0.69 (0.43–1.09) | 0.49 (0.28–0.88)b |
Hormones log-transformed. Model 1: unadjusted. Model 2: age, race (white/nonwhite), BMI, education, SBP, DBP, HOMA, LDL-C, HDL-C, triglycerides, lipid-lowering medications, blood pressure-lowering medications, and diabetes medications.
Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure.
a
P < 0.10.
b
P < 0.05.
c
P < 0.01.
d
FT estimated using ensemble allostery models.