Table 3.
SIRs for Differentiated Thyroid Cancer in Patients Diagnosed With Benign Thyroid Conditions, by Patient Characteristics, Denmark, 1978–2013
| Hyperthyroidism | Hypothyroidism | Thyroiditis | Nontoxic Nodular Goiter | Simple Goiter | Other/Unspecified Goiter | Thyroid Adenoma | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | |
| Overall | 118 | 3.26 (2.70–3.91) | 29 | 1.42 (0.95–2.04) | 17 | 3.25 (1.89–5.20) | 282 | 7.90 (7.01–8.88) | 45 | 8.25 (6.02–11.0) | 86 | 7.36 (5.89–9.09) | 25 | 7.95 (5.14–11.7) |
| Sex | ||||||||||||||
| Men | 14 | 5.43 (2.96–9.11) | 3 | 2.45 (0.51–7.17) | 1 | 3.09 (0.08–17.2) | 47 | 21.7 (16.0–28.9) | 5 | 17.7 (5.8–41.3) | 11 | 17.6 (8.78–31.5) | 10 | 32.9 (15.8–60.6) |
| Women | 104 | 3.10 (2.53–3.75) | 26 | 1.36 (0.89–1.99) | 16 | 3.26 (1.86–5.29) | 235 | 7.01 (6.14–7.97) | 40 | 7.73 (5.52–10.5) | 75 | 6.78 (5.34–8.50) | 15 | 5.28 (2.95–8.70) |
| Age at benign thyroid disease diagnosis | ||||||||||||||
| <30 y | 23 | 5.31 (3.36–7.97) | 5 | 2.46 (0.80–5.73) | 5 | 6.96 (2.25–16.2) | 50 | 12.5 (9.27–16.5) | 5 | 6.31 (2.04–14.7) | 14 | 7.70 (4.21–12.9) | 3 | 6.03 (1.24–17.6) |
| 30–49 y | 44 | 3.01 (2.19–4.04) | 10 | 1.30 (0.62–2.39) | 10 | 3.51 (1.68–6.45) | 139 | 6.90 (5.80–8.15) | 24 | 7.89 (5.06–11.8) | 49 | 7.74 (5.73–10.2) | 8 | 4.51 (1.94–8.88) |
| 50–69 y | 40 | 3.23 (2.31–4.40) | 9 | 1.26 (0.58–2.40) | 1 | 0.69 (0.02–3.85) | 68 | 6.94 (5.39–8.80) | 8 | 6.07 (2.61–12.0) | 17 | 5.92 (3.45–9.48) | 9 | 11.7 (5.37–22.3) |
| 70+ y | 11 | 2.28 (1.14–4.08) | 5 | 1.40 (0.45–3.27) | 1 | 4.60 (0.12–25.6) | 25 | 14.4 (9.32–21.3) | 8 | 26.3 (11.3–51.8) | 6 | 9.03 (3.31–19.7) | 5 | 46.5 (15.1–108) |
| Calendar year at benign thyroid disease diagnosis | ||||||||||||||
| 1978–1982 | 6 | 1.37 (0.50–2.99) | 3 | 2.40 (0.49–7.01) | 1 | 2.59 (0.07–14.4) | 29 | 4.88 (3.27–7.02) | 0 | — | 7 | 3.39 (1.36–6.99) | 2 | 5.68 (0.69–20.5) |
| 1983–1987 | 9 | 2.65 (1.22–5.04) | 0 | — | 2 | 5.17 (0.63–18.7) | 24 | 4.80 (3.07–7.14) | 0 | — | 6 | 4.05 (1.49–8.83) | 2 | 4.43 (0.54–16.0) |
| 1988–1992 | 5 | 1.35 (0.44–3.13) | 1 | 0.58 (0.01–3.21) | 1 | 2.48 (0.06–13.8) | 29 | 6.54 (4.38–9.40) | 1 | 5.99 (0.15–33.4) | 7 | 6.45 (2.59–13.3) | 3 | 5.87 (1.21–17.1) |
| 1993–1997 | 24 | 3.30 (2.12–4.91) | 3 | 0.90 (0.19–2.62) | 2 | 1.88 (0.23–6.77) | 60 | 8.45 (6.45–10.9) | 13 | 6.85 (3.65–11.7) | 19 | 9.99 (6.01–15.6) | 8 | 11.0 (4.75–21.7) |
| 1998–2002 | 29 | 3.41 (2.28–4.89) | 3 | 0.63 (0.13–1.84) | 4 | 3.34 (0.91–8.54) | 54 | 8.03 (6.03–10.5) | 12 | 7.12 (3.68–12.4) | 22 | 8.71 (5.46–13.2) | 5 | 9.91 (3.21–23.1) |
| 2003–2007 | 28 | 4.19 (2.78–6.05) | 7 | 1.29 (0.52–2.66) | 5 | 4.28 (1.39–9.98) | 49 | 11.0 (8.13–14.5) | 12 | 11.0 (5.66–19.1) | 14 | 6.63 (3.62–11.1) | 3 | 8.23 (1.70–24.0) |
| 2008–2013 | 17 | 7.73 (4.50–12.4) | 12 | 4.38 (2.26–7.65) | 2 | 3.21 (0.39–11.6) | 37 | 18.3 (12.9–25.2) | 7 | 17.3 (6.92–35.5) | 11 | 21.6 (10.8–38.6) | 2 | 8.48 (1.03–30.6) |
| Thyroid cancer histology | ||||||||||||||
| Papillary | 83 | 3.19 (2.54–3.95) | 21 | 1.43 (0.88–2.18) | 14 | 3.51 (1.92–5.89) | 174 | 6.54 (5.61–7.59) | 34 | 8.02 (5.55–11.2) | 59 | 6.69 (5.09–8.63) | 14 | 5.85 (3.20–9.82) |
| Follicular | 35 | 3.47 (2.41–4.82) | 8 | 1.41 (0.61–2.78) | 3 | 2.41 (0.50–7.04) | 108 | 11.9 (9.76–14.4) | 11 | 9.06 (4.51–16.2) | 27 | 9.43 (6.21–13.7) | 11 | 14.6 (7.28–26.1) |
| Thyroid cancer stage | ||||||||||||||
| Localized | 77 | 3.44 (2.72–4.31) | 19 | 1.54 (0.93–2.40) | 9 | 2.64 (1.21–5.01) | 182 | 7.71 (6.63–8.92) | 25 | 6.89 (4.45–10.2) | 56 | 7.23 (5.46–9.38) | 11 | 5.28 (2.63–9.45) |
| Regional/distant | 23 | 2.40 (1.52–3.60) | 5 | 0.92 (0.30–2.14) | 8 | 6.59 (2.84–13.0) | 73 | 8.80 (6.90–11.1) | 13 | 10.6 (5.63–18.1) | 19 | 7.06 (4.25–11.0) | 10 | 13.7 (6.56–25.2) |