Table 4.
SIRs for Differentiated Thyroid Cancer in Patients Diagnosed With Hyperthyroidism or Thyroiditis Subtypes, by Patient Characteristics, Denmark, 1994–2013
| Thyrotoxicosis With Diffuse Goiter (Graves) | Thyrotoxicosis With Toxic Nodules | Autoimmune Thyroiditis | Subacute Thyroiditis | Acute Thyroiditis | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | Cases | SIR (95% CI) | |
| Overall | 71 | 3.77 (2.94–4.75) | 26 | 3.94 (2.57–5.77) | 7 | 3.09 (1.24–6.37) | 4 | 3.76 (1.02–9.64) | 3 | 8.19 (1.69–23.9) |
| Sex | ||||||||||
| Men | 8 | 5.84 (2.52–11.5) | 2 | 4.87 (0.59–17.6) | 0 | — | 0 | — | 1 | 28.8 (0.73–160) |
| Women | 63 | 3.61 (2.77–4.61) | 24 | 3.88 (2.48–5.77) | 7 | 3.24 (1.30–6.67) | 4 | 4.12 (1.12–10.6) | 2 | 6.03 (0.73–21.8) |
| Age at benign thyroid disease diagnosis | ||||||||||
| <30 y | 17 | 7.69 (4.47–12.3) | 2 | 11.2 (1.36–40.5) | 3 | 9.02 (1.86–26.3) | 0 | — | 1 | 19.6 (0.50–109) |
| 30–49 y | 34 | 4.10 (2.84–5.72) | 9 | 4.67 (2.24–8.87) | 4 | 3.40 (0.92–8.69) | 3 | 4.53 (0.93–13.2) | 2 | 8.88 (1.07–32.1) |
| 50–69 y | 16 | 2.73 (1.56–4.43) | 12 | 3.91 (2.02–6.83) | 0 | — | 1 | 3.97 (0.10–22.1) | 0 | — |
| 70+ y | 4 | 1.62 (0.44–4.15) | 3 | 2.10 (0.43–6.14) | 0 | — | 0 | — | 0 | — |
| Calendar year at benign thyroid disease diagnosis | ||||||||||
| 1994–1997 | 11 | 2.26 (1.13–4.04) | 7 | 3.91 (1.57–8.06) | 1 | 2.19 (0.06–12.2) | 1 | 3.40 (0.09–19.0) | 2 | 7.45 (0.19–41.5) |
| 1998–2002 | 24 | 3.55 (2.27–5.28) | 8 | 3.17 (1.37–6.25) | 1 | 1.61 (0.04–8.99) | 1 | 2.93 (0.07–16.3) | 2 | 14.9 (1.80–53.6) |
| 2003–2007 | 23 | 4.25 (2.69–6.37) | 7 | 4.16 (1.67–8.56) | 4 | 5.59 (1.52–14.3) | 1 | 3.15 (0.08–17.6) | 0 | — |
| 2008–2013 | 13 | 7.25 (3.85–12.4) | 4 | 6.61 (1.80–16.9) | 1 | 2.12 (0.05–11.8) | 1 | 9.11 (0.23–50.7) | 0 | — |
| Time since benign thyroid disease diagnosis | ||||||||||
| 1 to <2 y | 11 | 5.29 (2.63–9.46) | 8 | 10.4 (4.50–20.6) | 1 | 3.13 (0.08–17.4) | 2 | 17.8 (2.16–64.4) | 0 | — |
| 2 to <5 y | 30 | 5.42 (3.66–7.74) | 10 | 5.06 (2.42–9.31) | 3 | 3.92 (0.81–11.4) | 0 | — | 0 | — |
| 5 to <10 y | 18 | 2.65 (1.57–4.19) | 3 | 1.27 (0.26–3.72) | 1 | 1.38 (0.03–7.67) | 1 | 2.62 (0.07–14.6) | 3 | 23.5 (4.83–68.5) |
| 10+ y | 12 | 2.70 (1.39–4.72) | 5 | 3.31 (1.07–7.72) | 2 | 4.44 (0.54–16.0) | 1 | 3.72 (0.09–20.7) | 0 | — |
| Thyroid cancer histology | ||||||||||
| Papillary | 56 | 3.97 (3.00–5.15) | 17 | 3.69 (2.15–5.90) | 6 | 3.39 (1.24–7.39) | 3 | 3.57 (0.73–10.4) | 3 | 10.4 (2.14–30.3) |
| Follicular | 15 | 3.17 (1.77–5.23) | 9 | 4.52 (2.07–8.59) | 1 | 2.03 (0.05–11.3) | 1 | 4.52 (0.11–25.2) | 0 | — |
| Thyroid cancer stage | ||||||||||
| Localized | 47 | 3.93 (2.88–5.22) | 19 | 4.71 (2.83–7.36) | 4 | 2.68 (0.73–6.87) | 3 | 4.19 (0.86–12.2) | 1 | 4.08 (0.10–22.7) |
| Regional/distant | 14 | 3.02 (1.65–5.06) | 6 | 3.40 (1.25–7.42) | 3 | 5.89 (1.21–17.2) | 1 | 4.33 (0.11–24.1) | 2 | 24.3 (2.94–87.7) |