Figure 5.

(A) Xenografted leiomyoma tumors from mice treated with RANK-Fc showed decreased tumor volume compared with mice treated with DPBS. (B) Representative images of regenerated tumors (red arrows) 4 weeks after engrafting. (C) A significantly lower number of cells expressing Ki67 (brown-stained) was seen in xenografted tumors from mice treated with RANK-Fc; n = 4. (D) Representative images of immunohistochemistry staining for Ki67, ×20. The inset in D (yellow rectangle) is the region in the red rectangle at a high magnification, ×2.7. The error bars are the standard error of the mean. E, estradiol; HPF, high-power field; P, progesterone.