Table 1.
Preclinical animal studies on blood miRNA biomarkers of epileptogenesis
| Model (SE) | Time point | Biofluid | Study design | Findings | References |
|---|---|---|---|---|---|
| Systemic KA in rats | 24 h | Whole blood | Profiling only | 10 miRNAs upregulated and 21 downregulated by ≥2‐fold in blood and brain (none passed FDR) | Liu et al. (2010)17 |
| Systemic PILO in rats | 24 h | Whole blood | Individual miRNA assays |
Increased miR‐34a Increased miR‐125a Increased miR‐22 Decreased miR‐21 |
Hu et al. (2011)62 |
| Electrical stimulation in rats | D, W, M | Plasma | Individual miRNA assays |
Increased miR‐21‐5p (W) Increased miR‐146a‐5p (M) Increased miR‐142‐5p (D) |
Gorter et al. (2014)46 |
| Systemic PILO in rats | L, C | Plasma | Profiling followed by validation of miRNAs |
Increased miR‐9a‐3p (L) Decreased miR‐598‐5p (L) Decreased miR‐300‐3p (L) Decreased miR‐142‐3p (C) |
Roncon et al. (2015)63 |
C, chronic (epilepsy); D, day; W, week (latency), M, month; L, latency; SE, status epilepticus; FDR, false discovery rate; KA, kainic acid; PILO, pilocarpine.