Table 2.
Clinical studies on blood miRNA biomarkers of epilepsy
| miRNA | Biofluid | Patient type | No. of patients | Validation cohort? | ROC curve | Other findings | References |
|---|---|---|---|---|---|---|---|
| let‐7d‐5p | Serum | Mixed | n = 147 | Yes | AUC = 0.79 | No correlations found with clinical variables including sz frequency | Wang, Yu et al. (2015)19 |
| miR‐106b‐5p | AUC = 0.88 | ||||||
| miR‐130a‐3p | AUC = 0.78 | ||||||
| miR‐146a‐5p | AUC = 0.78 | ||||||
| miR‐15a‐5p | AUC = 0.84 | ||||||
| miR‐194‐5p | AUC = 0.81 | ||||||
| miR‐301a‐3p | Serum | Mixed | n = 218 | Yes | AUC = 0.89 | Serum miR‐301a‐3p correlated with sz frequency (NHS3 score) | Wang, Tan et al. (2015)18 |
| miR‐30b‐5p | AUC = 0.68 | ||||||
| miR‐342‐5p | AUC = 0.72 | ||||||
| miR‐4446‐3p | AUC = 0.70 | ||||||
| miR‐194‐5p | AUC = 0.74 | ||||||
| miR‐106b | Serum | Mixed | n = 90 | No | AUC = 0.79 | Correlated with seizure severity score | An et al. (2016)65 |
| miR‐146a | AUC = 0.77 | ||||||
| miR‐129‐2‐3p | Plasma | TLE | n = 25 | No | AUC = 0.78 | Sun et al. (2016)67 | |
| miR‐134‐5p | Plasma | mTLE | n = 65 | Yes | AUC = 0.67 | Levels differed in drug‐responsive and drug‐resistant patients but no relation to seizure frequency | Avansini et al. (2017)72 |
| miR‐323a‐5p | Plasma | FCD | n = 30 | No | AUC = 0.74 | Correlated with duration of epilepsy and seizure frequency | Che et al. (2017)74 |
| miR‐4521 | Serum | FCD | n = 30 | No | AUC = 0.72 | Wang et al. (2016)64 | |
| miR‐3613‐5p | Plasma (exosomes) | mTLE | n = 43 | Yes | AUC = 0.84 | Yan et al. (2017)73 | |
| miR‐4668‐5p | AUC = 0.79 | ||||||
| miR‐8071 | AUC = 0.93 | ||||||
| miR‐197‐5p | AUC = 0.80 |
‐3p and ‐5p strands were not specified in some studies. AUC, area under the curve; FCD, Focal cortical dysplasia; mTLE, mesial temporal lobe epilepsy; ROC, receiver operating characteristic.