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. 2018 Oct 28;3(4):511–523. doi: 10.1002/epi4.12273

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© 2018 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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There is a temporary reduction of activity level 24 h after a seizure. A, Timeline for open field tests. There was no difference between control (n = 10) and seizure (n = 10) mice in total distance traveled (B), or horizontal movement frequency (C) at 24 h or 1 week after a seizure. Mice that experienced a seizure (D) spent significantly less time ambulating at 24 h later compared to controls but were no different at 1 week. In comparison, there was no difference between groups in (E) ambulatory episode count at 24 h or 1 week, indicating that the seizure group moved less during each ambulatory episode in comparison to controls. Preliminary measures of anxiety‐like behavior indicated no difference between groups in the percentage of time spent in the center versus surround of the open field (F), and no difference in the quantity of fecal boli (G). The bars represent the mean and the error bars indicate SEM. ** p < 0.01.