Table 1.

Comparison between NECAP1 patients and DNM1 patients

	Current report and Alazami et al.	PMID: 29427836; 29588952; 23934111; 26648591; 25262651; 25533962; 27806796; 27476654; 26611353; 28667181
Gene	NECAP1	DNM1
Inheritance	AR	AD
Number of patients	7	29
Seizure type at onset	Generalized tonic and clonic, generalized tonic, hemispasms	Infantile spasms, absence seizures, myoclonic, generalized tonic and clonic, head dropping
Age of onset	3 months, NA	0–13 months, 4.5 years
Antiepileptic drug response	+	+
EGG	Generalized slowing and frequent generalized epileptiform discharges	Slow background, multifocal discharges, hypsarrhythmia, modified hypsarrhythmia
GDD	100%	100%
Hypotonia	+	+
MRI	Thinning of the corpus callosum Delayed myelination for the patient's age Moderate supratentorial ventriculomegaly Generalized brain atrophy	Normal Generalized cerebral atrophy Delayed myelination for the patient's age Frontal lobe hypoplasia Mega cisterna magna Posterior skull flattening

AR, autosomal recessive; AD, autosomal dominant; EEG, electroencephalography; GDD, global developmental delay; MRI, magnetic resonance imaging; NA, not available.