TABLE 2.
Risk of neuroblastoma associated with maternal conditions and pregnancy characteristics by age at diagnosis.
| All neuroblastoma (n=245) | Diagnosis before 1 year (n=106) | Diagnosis at 1 year or older (n=139) | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Controls No. | Cases No. | OR (95% CI)1 | Controls No. | Cases No. | OR (95% CI) | Controls No. | Cases No. | OR (95% CI) | |
|
| |||||||||
| Maternal age (years completed) | |||||||||
|
| |||||||||
| <20 | 59 | 7 | 0.58 (0.26, 1.29) | 24 | 1 | 35 | 6 | 0.86 (0.35, 2.12) | |
| 20 - 34 | 1053 | 214 | 1.00 | 457 | 95 | 1.00 | 596 | 119 | 1.00 |
| 35+ | 113 | 24 | 1.04 (0.65, 1.65) | 49 | 10 | 0.98 (0.48, 2.00) | 64 | 14 | 1.09 (0.59, 2.01) |
|
| |||||||||
| Maternal parity | |||||||||
| 1 | 534 | 104 | 1.00 | 227 | 41 | 1.00 | 307 | 63 | 1.00 |
| 2-3 | 611 | 118 | 0.99 (0.75, 1.32) | 273 | 54 | 1.09 (0.70, 1.68) | 338 | 64 | 0.92 (0.63, 1.35) |
| ≥ 4 | 80 | 23 | 1.48 (0.89, 2.45) | 30 | 11 | 2.04 (0.94, 4.41) | 50 | 12 | 1.17 (0.59, 2.31) |
|
| |||||||||
| Gestational age (completed weeks) | |||||||||
|
| |||||||||
| < 37 | 61 | 11 | 0.90 (0.47, 1.74) | 31 | 3 | 0.47 (0.14, 1.56) | 30 | 8 | 1.39 (0.61, 3.16) |
| 37- 42 | 1121 | 223 | 1.00 | 484 | 100 | 1.00 | 641 | 123 | 1.00 |
| ≥ 43 | 36 | 11 | 1.53 (0.77, 3.02) | 13 | 3 | 1.12 (0.31, 4.02) | 24 | 9 | 1.93 (0.88, 4.22) |
|
| |||||||||
| Maternal anemia during pregnancy | |||||||||
|
| |||||||||
| No | 1200 | 232 | 1.00 | 520 | 99 | 1.00 | 680 | 133 | 1.00 |
| Yes | 25 | 13 | 2.72 (1.36, 5.44) | 10 | 7 | 3.89 (1.40, 10.9) | 15 | 6 | 2.04 (0.78, 5.34) |
|
| |||||||||
| Maternal hypertension | |||||||||
|
| |||||||||
| No | 1150 | 239 | 1.00 | 495 | 103 | 1.00 | 655 | 136 | 1.00 |
| Yes | 75 | 6 | 0.36 (0.15, 0.87) | 35 | 3 | 0.37 (0.10, 1.32) | 40 | 3 | 0.36 (0.11, 1.18) |
1
OR, odds ratio; CI, confidence interval.