Table 5.
Risk of neuroblastoma by site of diagnosis associated with selected conditions of pregnancy and the perinatal period.
| Adrenal gland (n=62) | Peripheral nerves (n=118) | Brain (n=33) | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Controls No. | Cases No. | OR (95% CI) | Controls No. | Cases No. | OR (95% CI) | Controls No. | Cases No. | OR (95% CI) | |
|
| |||||||||
| Maternal anemia during pregnancy | |||||||||
|
| |||||||||
| No | 302 | 57 | 1.0 | 581 | 113 | 1.0 | 160 | 33 | |
| Yes | 8 | 5 | 2.19 (0.88, 5.46) | 9 | 5 | 1.86 (0.76, 4.54) | 5 | 0 | |
|
| |||||||||
| Birth weight (grams) | |||||||||
| < 2500 | 11 | 2 | 0.90 (0.22, 3.68) | 23 | 3 | 0.65 (0.21, 2.05) | 4 | 3 | 2.06 (0.63, 6.76) |
| 2500 - <4500 | 287 | 56 | 1.0 | 541 | 109 | 1.0 | 154 | 29 | 1.0 |
| ≥ 4500 | 11 | 4 | 2.00 (0.72, 5.50) | 25 | 5 | 0.76 (0.31, 1.87) | 7 | 1 | |
|
| |||||||||
| 1-minute Apgar score | |||||||||
| >7 | 289 | 54 | 1.0 | 553 | 104 | 1.0 | 153 | 31 | 1.0 |
| ≤ 7 | 18 | 7 | 1.91 (0.87, 4.19) | 34 | 12 | 1.64 (0.90, 2.98) | 12 | 2 | 0.83 (0.20, 3.46) |
| Unknown | 3 | 1 | 3 | 2 | 2.56 (0.63, 10.37) | 0 | 0 | ||
|
| |||||||||
| Head circumference | |||||||||
| <32 cm | 14 | 1 | 13 | 1 | 4 | 2 | 1.58 (0.38, 6.61) | ||
| 32-37 cm | 281 | 53 | 1.0 | 544 | 107 | 1.0 | 155 | 29 | 1.0 |
| >37 cm | 13 | 7 | 2.87 (1.30, 6.30) | 27 | 6 | 0.99 (0.43, 2.25) | 5 | 2 | 1.48 (0.35, 6.19) |
|
| |||||||||
| Hemolytic disease without kernicterus | |||||||||
|
| |||||||||
| No | 302 | 61 | 563 | 110 | 1.0 | 159 | 31 | 1.0 | |
| Yes | 8 | 1 | 27 | 8 | 2.01 (0.98, 4.13) | 6 | 2 | 1.75 (0.42, 7.30) | |