Table 4.
GO terms enriched in target genes
| GO ID | GO term | Count | P-value | Genes | miRNA |
|---|---|---|---|---|---|
| BP | |||||
| GO:0002064 | Epithelial cell development | 8 | 1.52×10−5 | B4GALT1, SHROOM3, HYDIN, ONECUT1, SLC9A4, ONECUT2, TP63, SLC4A5 | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0008360 | Regulation of cell shape | 28 | 2.42×10−4 | GNA13, DMTN, SHROOM3, WASF3, HEXB, FERMT2, ATP10A, RHOQ, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0001764 | Neuron migration | 22 | 6.93×10−4 | DCC, TUBB2B, SOX1, NDN, ASTN1, FZD3, SPOCK1, NTN1, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0008654 | Phospholipid biosynthetic process | 12 | 8.80×10−4 | PPARD, AGPAT5, LPGAT1, SH3GLB1, SERAC1, HEXB, MBOAT2, PISD, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0030335 | Positive regulation of cell migration | 31 | 2.05×10−3 | CGA, ONECUT1, WASH1, ONECUT2, LRRC15, SEMA5A, ITGAV, SEMA3F, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0043401 | Steroid hormone- mediated signaling pathway | 14 | 2.06×10−3 | PPARD, THRB, ESRRB, RXRA, PAQR8, RORB, NR2C2, NR1H2, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0030522 | Intracellular receptor signaling pathway | 11 | 2.15×10−3 | NOTCH2, PPARD, NCOA2, THRB, NR1D2, ESRRB, RORB, NR2F2, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0007010 | Cytoskeleton organization | 27 | 4.47×10−3 | DMTN, TUBB2B, WASF3, ABLIM3, NEDD9, RHOU, DMD, STRIP2, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| CC | |||||
| GO:0030864 | Cortical actin cytoskeleton | 12 | 1.46×10−3 | EEF1A1, PPP1R9A, SHROOM2, NF2, MED28, SHROOM4, LASP1, FLOT2, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0014069 | Postsynaptic density | 31 | 1.57×10−3 | NETO2, DMTN, LZTS1, SYNDIG1, CNN3, CPEB3, BMPR2, SPOCK1, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0055038 | Recycling endosome membrane | 12 | 1.79×10−3 | SCAMP1, RAP2B, RAB11FIP4, RAP2A, RAB11FIP2, RAP2C, WASH1, SLC26A7, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0000932 | Cytoplasmic mRNA processing body | 17 | 1.83×10−3 | NANOS2, CNOT2, BTBD6, APOBEC3H, CNOT7, APOBEC3F, CAPRIN1, PATL1, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0043235 | Receptor complex | 23 | 2.93×10−3 | EGFR, RNMT, IL23R, OLR1, LDLR, RXRA, TGFBR1, LIFR, SMAD3, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0000139 | Golgi membrane | 75 | 4.42×10−3 | SLC9A8, OSBP, SEC24A, NDST1, VAPB, FAM20B, CNGB1, RHOU, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0031901 | Early endosome membrane | 21 | 4.68×10−3 | EGFR, MMGT1, SYNDIG1, WASH1, PML, EEA1, CFTR, WLS, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0005884 | Actin filament | 14 | 5.93×10−3 | MYO5A, DMTN, MYO1B, RHOQ, ACKR2, ACTN2, MYO9B, GNG12, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0015629 | Actin cytoskeleton | 33 | 5.99×10−3 | MTSS1, DMTN, CNN3, SHROOM4, ONECUT2, KNTC1, PDLIM2, ARHGAP35, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| MF | |||||
| GO:0003707 | Steroid hormone receptor activity | 14 | 1.82×10−3 | PPARD, THRB, ESRRB, RXRA, PAQR8, RORB, NR2C2, NR1H2, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0005254 | Chloride channel activity | 13 | 3.95×10−3 | GABRG1, SLC1A4, GABRG2, GABRG3, GABRA4, CLIC4, SLC26A7, CLIC5, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0005112 | Notch binding | 7 | 4.85×10−3 | NOV, NOTCH1, HIF1AN, DNER, AAK1, JAG1, GALNT11 | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0003779 | Actin binding | 41 | 4.86×10−3 | MYO5A, LRRC10, DMTN, SHROOM2, CNN3, WASH1, WASF3, IMPACT, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | 10 | 5.30×10−3 | NR1H2, PPARD, NR1D2, ESRRB, RXRA, RORB, NR2F2, NR1H4, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 14 | 7.12×10–3 | CDX2, ESRRB, NFKB1, MBD2, GZF1, NONO, ARX, FLI1, etc | hsa-miR-508 hsa-miR-509-2 hsa-miR-526b |
Abbreviations: BP, biological process; CC, cellular component; GO, gene ontology; MF, molecular function.