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. 2018 Sep 12;27(24):4333–4343. doi: 10.1093/hmg/ddy319

Figure 1.

Figure 1

Association and conditional testing for the 13 polymorphisms at 5q15. (A) Initial association testing mapped the strongest association to rs10044354 in LNPEP (Dark red). (B) Conditioning on rs10044354 revealed independent association for the C allele of rs2287987 (amino acid position 349 in ERAP1) and variants in tight LD (rs10050860 and rs17482075 in dark blue) in ERAP1. (C) Conditioning on both rs10044354 and rs2287987 removed the bulk of the signal (rs30187, P = 0.05). Plot framework was generated by LocusZoom (53) and edited for graphical purposes.