Figure 1.

Growth retardation and early mortality in Tsc2 ^ff FoxD1 ^GC+ mice. (A) Tsc2^ffFoxD1^GC+ (Mutant) mice have a shortened body and tail length in comparison to control littermates (***denotes P < 0.001, **** denotes P < 0.0001). (B)Tsc2^ffFoxD1^GC+mice have a lower body weight than controls in both sexes (n = 14–34 for the 4 categories are shown). (C) Survival curve of Tsc2^ffFoxD^GC+ mice (n = 40; median, 115 days) compared to control littermates (n = 35). (D) Photograph of representative adult Tsc2^ffFoxD1^GC+ mouse (age, 6 months) in comparison to control littermate.