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Multifocal HPC in the tongue and face of Tsc2 ff FoxD1 GC+ mice. H&E stains and IHC using serial sections for pS6 (S244/246), vimentin, NG2, PDGFR-β and CD31 are shown for two different HPC occurring in the tongue and face. Note pS6 (S244/246) expression by the pericyte tumor cells reflecting mTORC1 activation. Note the expression of typical markers (vimentin, NG2, PDGFR-β) of pericytes in the tumors, and of CD31 by ECs but not in tumor cells.
