Table 1.
Genetic variants associated with menstrual cycle length
Region | Nearest gene(s) | SNP | Alleles, other allele/effect allele (EAF) | UKBB | EGCUT | Meta-analysis | |||
---|---|---|---|---|---|---|---|---|---|
Effect (SD of the binned menstrual cycle length) | P-value | Effect (SD of the binned menstrual cycle length) | P | P | P heterogeneity | ||||
11:30226528 | FSHB | rs11031006 | A/G (0.86) | −0.16 (0.01) | 1.1 × 10−38 | −0.06 (0.02) | 6.6 ![]() |
3.6 ![]() |
3.7 × 10−6 |
1:199891438 | NR5A2 | rs6670899 | A/C (0.57) | −0.05 (0.01) | 1.1 × 10−10 | −0.04 (0.01) | 4.7 ![]() |
6.6 ![]() |
0.43 |
8:25248615 | DOCK5/ GNRH1 | rs13261573 | A/G (0.75) | −0.07 (0.01) | 1.7 × 10−11 | −0.02 (0.01) | 7.0 ![]() |
1.2 ![]() |
0.02 |
11:101044203 | PGR/PGR-AS1 | rs471811 | C/T (0.31) | −0.03 (0.01) | 4.8 × 10−5 | −0.06 (0.01) | 6.3 ![]() |
3.0 ![]() |
0.33 |
11:2118860 | IGF2/INS-IGF2 | rs11042596 | G/T (0.34) | 0.04 (0.01) | 1.1 × 10−7 | 0.02 (0.01) | 3.5 ![]() |
4.5 ![]() |
0.21 |
SD - standard deviation.