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. 2018 Nov 19;37(23):e100801. doi: 10.15252/embj.2018100801

Figure 1. Model for PNRC1‐mediated snoRNA decapping in the nucleolus to regulate ribosome biogenesis.

Figure 1

(A) PNRC1 binds to Dcp1/Dcp2 and relocalizes the mRNA decapping complex from cytoplasmic P‐bodies to the nucleolus. (B) PNRC1‐bound decapping complex selectively cleaves the 5′ cap on U3 and U8 snoRNAs. (C) Decapping of U3 and U8 snoRNAs prevents cleavage and processing of the 18S and 28S rRNA isoforms from the 47S pre‐rRNA. (D) Downregulation of 18S and 28S rRNA leads to slowed ribosome biogenesis and tumor suppression.