. 2016 Dec 22;140(1):158–170. doi: 10.1093/brain/aww259

Table 3.

Multivariable analysis between quintiles of WMH volume and 3-month modified Rankin Scale score after stratification by stroke subtype

	Large artery atherosclerosis		Small vessel occlusion		Cardioembolism
	(n = 1965)		(n = 895)		(n = 1035)
	OR (95% CI)^a	CMH P-value^b	OR (95% CI)^a	CMH P-value^b	OR (95% CI)^a	CMH P-value^b
First quintile	Reference		Reference		Reference
Second quintile	1.26 (0.97–1.64)	0.95	1.17 (0.77–1.76)	1.00	1.21 (0.83–1.75)	0.62
Third quintile	1.45 (1.10–1.90)	0.04	1.46 (0.98–2.19)	0.95	1.19 (0.81–1.73)	0.71
Fourth quintile	1.86 (1.41–2.47)	0.01	1.37 (0.89–2.13)	0.03	1.23 (0.84–1.82)	0.44
Fifth quintile	1.89 (1.41–2.54)	0.004	1.98 (1.23–3.18)	0.74	1.62 (1.09–2.40)	0.92
P-value	<0.001^c	0.01^d	0.17^c	0.10^d	0.47^c	0.19^d

Data for patients with undetermined (n = 1021) or other determined (n = 119) strokes are not shown.

^aOrdinal logistic regression analysis using 3-month modified Rankin Scale scores for the imputed dataset, after adjustment for age, admission NIHSS score, sex, body mass index, hypertension, diabetes, hyperlipidaemia, smoking, coronary artery disease, atrial fibrillation, prior use of statin, thrombolysis, haemoglobin, total cholesterol, fasting glucose, and log-transformed infarct volume on diffusion-weighted MRI.

^bCochran-Mantel-Haenszel (CMH) test with adjustment for age, sex, admission NIHSS score, and thrombolysis.

^cχ² trend test across quintiles.

^dP-value from the Cochran-Mantel-Haenszel test for the overall effect of WMH quintiles on the distributions of modified Rankin Scale scores.