TABLE 4.
Combined Two-Point Linkage Analysis in Four Families with HIBM and PDB
| Marker | LOD score at recombination fraction θ = | Marker | LOD score at recombination fraction θ = | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.00 | 0.01 | 0.02 | 0.03 | 0.04 | 0.05 | 0.10 | 0.00 | 0.01 | 0.02 | 0.03 | 0.04 | 0.05 | 0.10 | ||
| D9S1853 | −0.68 | 2.75 | 3.02 | 3.14 | 3.20 | 3.23 | 3.09 | D9S1805 | 8.45 | 8.40 | 8.33 | 8.24 | 8.14 | 8.01 | 7.27 |
| 1 | 2.10 | 2.16 | 2.19 | 2.21 | 2.21 | 2.21 | 2.09 | 1 | 3.74 | 3.79 | 3.82 | 3.83 | 3.83 | 3.81 | 3.62 |
| 2 | −2.79 | 0.59 | 0.82 | 0.93 | 0.99 | 1.02 | 1.00 | 2 | 1.95 | 1.89 | 1.84 | 1.79 | 1.74 | 1.68 | 1.41 |
| D9S52 | 4.24 | 4.19 | 4.13 | 4.08 | 4.01 | 3.95 | 3.59 | 3 | 1.32 | 1.31 | 1.29 | 1.28 | 1.26 | 1.24 | 1.12 |
| 1 | 3.91 | 3.87 | 3.83 | 3.78 | 3.73 | 3.68 | 3.36 | 4 | 1.44 | 1.41 | 1.38 | 1.34 | 1.31 | 1.28 | 1.12 |
| 2 | 0.32 | 0.31 | 0.30 | 0.29 | 0.28 | 0.27 | 0.23 | D9S1791 | 9.29 | 9.11 | 8.92 | 8.72 | 8.54 | 8.33 | 7.30 |
| D9S43 | 3.42 | 6.70 | 6.85 | 6.87 | 6.84 | 6.78 | 6.22 | 1 | 4.66 | 4.60 | 4.54 | 4.47 | 4.41 | 4.33 | 3.94 |
| 1 | 6.81 | 6.70 | 6.59 | 6.47 | 6.36 | 6.24 | 5.60 | 2 | 2.96 | 2.88 | 2.81 | 2.73 | 2.65 | 2.58 | 2.19 |
| 2 | −3.39 | −0.00 | 0.26 | 0.40 | 0.48 | 0.54 | 0.63 | 3 | 1.86 | 1.81 | 1.75 | 1.70 | 1.65 | 1.59 | 1.33 |
| 3 | 2.00 | 1.97 | 1.93 | 1.90 | 1.86 | 1.82 | 1.62 | 4 | −0.19 | −0.18 | −0.18 | −0.18 | −0.17 | −0.17 | −0.15 |
| 4 | 0.43 | 0.43 | 0.43 | 0.43 | 0.42 | 0.42 | 0.38 | D9S50 | 6.86 | 6.71 | 6.57 | 6.43 | 6.27 | 6.13 | 5.34 |
| D9S165 | 7.67 | 7.57 | 7.46 | 7.34 | 7.21 | 7.08 | 6.35 | 1 | 3.66 | 3.60 | 3.54 | 3.48 | 3.41 | 3.34 | 2.98 |
| 1 | 6.11 | 6.02 | 5.94 | 5.85 | 5.75 | 5.66 | 5.13 | 2 | 1.18 | 1.15 | 1.12 | 1.09 | 1.06 | 1.03 | 0.87 |
| 2 | 0.44 | 0.45 | 0.45 | 0.45 | 0.45 | 0.44 | 0.38 | 3 | 2.17 | 2.11 | 2.06 | 2.00 | 1.94 | 1.89 | 1.60 |
| 3 | 1.46 | 1.43 | 1.39 | 1.35 | 1.32 | 1.28 | 1.10 | 4 | −0.15 | −0.15 | −0.15 | −0.14 | −0.14 | −0.13 | −0.11 |
| 4 | −0.34 | −0.33 | −0.32 | −0.31 | −0.31 | −0.30 | −0.26 | D9S1874 | 2.94 | 6.13 | 6.24 | 6.39 | 6.39 | 6.37 | 5.99 |
| D9S1118 | 8.61 | 8.43 | 8.25 | 8.06 | 7.87 | 7.68 | 6.69 | 1 | 3.93 | 3.91 | 3.88 | 3.84 | 3.80 | 3.76 | 3.50 |
| 1 | 4.40 | 4.34 | 4.28 | 4.21 | 4.14 | 4.07 | 3.67 | 2 | −2.76 | 0.46 | 0.71 | 0.83 | 0.90 | 0.94 | 0.97 |
| 2 | 1.64 | 1.58 | 1.52 | 1.47 | 1.42 | 1.36 | 1.10 | 3 | 0.92 | 0.93 | 0.93 | 0.94 | 0.94 | 0.94 | 0.91 |
| 3 | 2.00 | 1.94 | 1.89 | 1.83 | 1.77 | 1.72 | 1.44 | 4 | 0.85 | 0.83 | 0.80 | 0.78 | 0.75 | 0.73 | 0.61 |
| 4 | 0.57 | 0.57 | 0.56 | 0.55 | 0.54 | 0.53 | 0.48 | D9S1844 | 4.29 | 4.19 | 4.09 | 3.99 | 3.89 | 3.80 | 3.30 |
| D9S304 | 8.27 | 8.10 | 7.95 | 7.78 | 7.60 | 7.42 | 6.47 | 1 | 2.60 | 2.55 | 2.51 | 2.47 | 2.42 | 2.38 | 2.15 |
| 1 | 5.05 | 4.96 | 4.88 | 4.79 | 4.69 | 4.60 | 4.09 | 2 | 1.69 | 1.64 | 1.58 | 1.53 | 1.47 | 1.42 | 1.15 |
| 2 | 1.52 | 1.46 | 1.40 | 1.35 | 1.29 | 1.23 | 0.95 | D9S234 | −3.58 | 6.16 | 6.59 | 6.77 | 6.84 | 6.85 | 6.51 |
| 3 | 1.15 | 1.12 | 1.10 | 1.07 | 1.05 | 1.02 | 0.89 | 1 | −0.90 | 4.91 | 5.11 | 5.18 | 5.20 | 5.18 | 4.89 |
| 4 | 0.55 | 0.56 | 0.57 | 0.57 | 0.57 | 0.57 | 0.54 | 2 | −2.68 | 1.25 | 1.48 | 1.59 | 1.64 | 1.67 | 1.63 |
| D9S1788 | 3.33 | 6.63 | 6.76 | 8.21 | 6.72 | 6.64 | 6.01 | D9S1862 | 1.09 | 4.86 | 5.02 | 5.06 | 5.04 | 5.00 | 4.62 |
| 1 | −1.67 | 1.76 | 2.03 | 2.16 | 2.24 | 2.29 | 2.32 | 1 | 5.68 | 5.59 | 5.49 | 5.40 | 5.30 | 5.20 | 4.69 |
| 2 | 1.12 | 1.08 | 1.04 | 1.01 | 0.97 | 0.93 | 0.74 | 2 | −4.59 | −0.73 | −0.47 | −0.34 | −0.26 | −0.20 | −0.07 |
| 3 | 2.73 | 2.67 | 2.61 | 2.55 | 2.49 | 2.43 | 2.12 | D9S1879 | −6.86 | 1.30 | 1.78 | 2.01 | 2.14 | 2.21 | 2.18 |
| 4 | 1.15 | 1.12 | 1.08 | 1.05 | 1.02 | 0.99 | 0.83 | 1 | −4.54 | −0.25 | 0.01 | 0.15 | 0.24 | 0.29 | 0.40 |
| D9S1845 | 9.04 | 8.89 | 8.72 | 8.55 | 8.38 | 8.20 | 7.24 | 2 | −2.32 | 1.55 | 1.77 | 1.86 | 1.90 | 1.91 | 1.78 |
| 1 | 3.72 | 3.71 | 3.68 | 3.65 | 3.62 | 3.58 | 3.32 | D9S1800 | −8.75 | 0.89 | 1.41 | 1.68 | 1.84 | 1.94 | 2.05 |
| 2 | 2.12 | 2.06 | 2.01 | 1.95 | 1.90 | 1.84 | 1.56 | 1 | −3.95 | 1.78 | 2.02 | 2.12 | 2.18 | 2.20 | 2.12 |
| 3 | 2.12 | 2.07 | 2.01 | 1.96 | 1.90 | 1.85 | 1.58 | 2 | −4.18 | −0.89 | −0.60 | −0.44 | −0.34 | −0.26 | −0.07 |
| 4 | 1.08 | 1.05 | 1.02 | 0.99 | 0.96 | 0.93 | 0.78 | D9S1799 | −0.76 | 3.21 | 3.49 | 3.65 | 3.74 | 3.79 | 3.75 |
| 1 | 2.87 | 2.90 | 2.93 | 2.94 | 2.94 | 2.94 | 2.84 | ||||||||
| 2 | −3.63 | 0.30 | 0.57 | 0.71 | 0.79 | 0.85 | 0.92 | ||||||||
Note. The combined LOD scores for each marker are provided in the first row adjacent to the marker name. Independent scores for each family are given below the marker name. A numerical identification (1–4) is given for each pedigree and corresponds to genotype data presented in Figs. 1–4, respectively.