Table 3. Validated gene targets of most abundant miRNA.
hsa-miR-378a-3p | hsa-miR-340-5p | hsa-miR-92b-3p | hsa-miR-381-3p |
CDK6 [95, 96] | AKT1 [97, 98] | CDKN1C [99–101] | ANO1 |
CYP19A1 [102] | CCND1 | DAB2IP [103, 104] | CD1C [105] |
GALNT7 | CCND2y [96] | DKK3 [106, 107] | GJA1 [108, 109] |
GLI3 [110] | CCNG2 [111, 112] | ITGA6 [113, 114] | HDAC4 |
GOLT1A | CDK6 [95] | ITGAV [115] | ID1 |
GRB2 [116, 117] | HNRNPA2B1 [118] | NLK | NFKBIA |
IGF1R [119] | IL4 [120] | PRMT5 [121] | P2RX5 |
KSR1 | KRAS [122] | PTEN [123, 124] | TBC1D9 |
MAPK1 [125, 126] | MDM2 [127, 128] | RAB23 [113, 129] | TWIST1 [130, 131] |
MSC | MECP2 [132] | RECK [133, 134] | WEE1 |
MYC [135] | MET | SLC15A1 | |
NPNT | MITF [130] | SMAD3 [136] | |
PGR [137] | PTBP1 | SMAD7 [88] | |
RUNX1 [138] | PUM1 [139, 140] | ||
SUFU | PUM2 | ||
TGFB2 [141] | RHOA [142, 143] | ||
TOB2 [144] | ROCK1 [115] | ||
TUSC2 [145] | SKP2 [146] | ||
VEGFA [147] | SOX2 | ||
VIM | STAT3 [148–150] | ||
WNT10A | |||
hsa-miR-421 | hsa-miR-106b-3p | hsa-miR-654-3p | |
ATM | BMP2 [123] | CDKN1A [151–153] | |
CASP3 [154] | PTEN [123, 124] | ||
CBX7 | |||
CDH1 [155] | |||
FOXO4 [156–158] | |||
RBMXL1 | |||
SIRT3 [159] | |||
SMAD4 [160] |
Table showing the 75 validated targets, found using miRTarBase [94], for the most abundant miRNA in our samples that were not found in adult plasma. Where available, the citation which supports a link between the gene and pregnancy is show.