FIG. 8.
Schematic representation of CD38-mediated intracellular Ca2+ secondary messenger signaling. CD38 is also an NADase, which primarily regulates intracellular levels of NAD+ and its physiological processes. CD38 also catalyzes a base exchange between NADP and NA, leading to the formation of NAADP, which is also used as a hydrolytic substrate. NAADP, nicotinic acid adenine dinucleotide phosphate. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars