Fig 2. Collagen degradation biomarker levels in asymptomatic controls and SSc groups.

A: Type I collagen degradation. B: Type III collagen degraded by aggrecanses. C: Type III collagen degraded by MMPs. D: Type IV collagen degradation. E: Type V collagen degradation. F: Type VI collagen degradation. Repeated measures ANOVA (Kruskal-Wallis with Dunn’s multiple comparisons test) was used for statistical analysis, between asymptomatic controls, late and early diffuse SSc. Asymptomatic controls: n = 20, early SSc: n = 20 and late SSc: n = 20.