Table 1. Toxicity of permethrin +/- the CYP inhibitor PBO to the susceptible (ROCK) and resistant (SP and CKR) strains of A. aegypti.
| Insecticide | Strain | LD50 (95% CI) | Slope (SE) | n | P# | RR‡ |
|---|---|---|---|---|---|---|
| Permethrin | ROCK | 1.03 (1.01–1.06) | 8.1 (0.4) | 400 | 0.23 | - |
| Permethrin | CKR | 115* (95.2–138) | 2.9 (0.4) | 480 | 0.09 | 112 |
| Permethrin | SP | 367*^ (302–447) | 3.0 (0.5) | 455 | 0.12 | 356^ |
| PBO+permethrin | ROCK | 0.29 (0.27–0.31) | 6.2 (0.3) | 420 | 0.23 | - |
| PBO+permethrin | CKR | 22.3* (22.1–22.6) | 6.9 (0.1) | 480 | 0.45 | 77 |
| PBO+permethrin | SP | 20.3* (20.2–20.4) | 7.3 (0.1) | 400 | 0.62 | 70 |
The average weight of ROCK, CKR and SP females used in the bioassays was 1.9, 2.5 and 1.8 mg, respectively.
#p value from chi squared test for fit of the data to the log-dose probit line.
‡RR = Resistance Ratio (LD50 of resistant strain/LD50 of susceptible strain).
*Significantly greater than ROCK.
^Significantly greater than CKR.