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Iminosugar inhibitors. A: Chemical structures: NJ (6), DNJ (7), IFJ (8), noeuromycin (9), NB-DNJ (10), NN-DNJ (11), AMP-DNM (12), and l-idose-configured iminosugar substituted with methoxypentyl-adamantyl (13). B: IFG is protonated by the acid/base amino acid and mimics the positive charge of the oxocarbenium ion transition state.
