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. 2018 Oct 17;59(12):2368–2382. doi: 10.1194/jlr.M090043

TABLE 3.

Alphabetical list of proteins, which may have differential abundance in the Apoe−/− (KO) versus WT retina

Protein (total number. of detected peptides) Peptides with Significant Changes in Abundance Peptide Intensity (a.u.) × 106 Peptide Intensity Ratio, KO/WT Number of Peptides with Nonsignificant Changes in Abundance, KO/WT
Apoe-/-, Mean ± SD WT, Mean ± SD
Proteins with decreased abundance in the Apoe−/− versus WT retina
 CRYBB1 (8) VGSITVSGGTWVGYQYPGYR 0.8 ± 0.5 6.7 ± 3.3 0.12 7 (↓)
 CRYBB2 (9) GEYPRWDSWTSSR 0.7 ± 0.7 22.4 ± 18.2 0.03 8 (↓)
 FGB (4) YCGLPGEYWLGNDK 3.3 ± 1.5 5.0 ± 4.2 0.66 2 (↓)
 GSN (11) SEDCFILDHGR 2.2 ± 3.8 9.5 ± 3.3 0.24 10 (↓)
 HIST1H4K (14) VFLENVIRDAVTYTEHAK 67.5 ± 114.8 1,378.0 ± 399.4 0.05 10 (↓)
 REEP5 (4) HESQVDSVVK 3.0 ± 2.3 5.1 ± 4.4 0.59 3 (↓)
Proteins with Increased Abundance in the Apoe−/− versus WT Retina
 SCG2 (5) PNGLVEPEQDLELAVDLDDIPEADLDRPDMFQSK 3.0 ± 0.7 2.0 ± 0.8 1.5 3 (↑)
 ZC3H4 (7) LDSFSQVGPGSETVTQK 3.2 ± 1.2 1.6 ± 0.3 1.90 6 (↑)

One peptide in each of these proteins had a significantly different abundance (P ≤ 0.05) between the genotypes, and two or more of the remaining peptides showed the same direction of change in abundance (nonsignificant); in the latter, the KO/WT peptide intensity ratio was ≤0.7 (↓) or ≥1.3 (↑). a.u., arbitrary units.