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| EC50 (μM) | |||
|---|---|---|---|
| Variant\Compound | 6 | 8 | 9 |
| WT | no effect | 4.6 ± 0.06 | 7.7 ± 2 |
| Y51S | no effect | >10 | >10 |
| G71I | no effect | >10 | no effect |
| Y51S/G71I | no effect | >10 | no effect |
| R244A | no effect | >10 | 6.2 ± 0.8 |
| R244H | no effect | >10 | 7.6 ± 1 |
Compounds were titrated from 0.04 to 9.5 μM, and reactions were performed in triplicate with values reported as mean ± s.e.m.
