Table 3.
Diabetes odds ratios for categories of cumulative arsenic water concentrations lagged 40 years stratified by healthy (<25 kg/m2), overweight (≥25 to <30 kg/m2), and obese (≥30 kg/m2) BMI
| BMI level (kg/m2) |
Arsenic level (µg/L) |
Diabetes |
Unadjusted OR (95% CI) |
Adjusted* OR (95% CI) |
|
|---|---|---|---|---|---|
| Yes | No | ||||
| Healthy (<25) |
0–609 | 18 | 102 | 1.00 (Ref) | 1.00 (Ref) |
| 610–5279 | 16 | 116 | 0.78 (0.38–1.61) | 0.75 (0.36–1.56) | |
| ≥5280 | 32 | 123 | 1.47 (0.78–2.78) | 1.45 (0.74–2.84) | |
| p-trend | 0.08 | 0.09 | |||
| Overweight (≥25 to <30) |
0–609 | 27 | 113 | 1.00 (Ref) | 1.00 (Ref) |
| 610–5279 | 34 | 117 | 1.22 (0.69–2.15) | 1.12 (0.62–2.00) | |
| ≥5280 | 43 | 111 | 1.62 (0.94–2.80) | 1.34 (0.76–2.35) | |
| p-trend | 0.08 | 0.31 | |||
| Obese (≥30) |
0–609 | 25 | 61 | 1.00 (Ref) | 1.00 (Ref) |
| 610–5279 | 18 | 45 | 0.98 (0.48–2.00) | 1.04 (0.49–2.20) | |
| ≥5280 | 18 | 20 | 2.20 (1.00–4.83) | 2.64 (1.14–6.11) | |
| p-trend | 0.04 | 0.02 | |||
Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio; Ref, reference group
*
Adjusted for age (<60, 60–70, >70 years old), sex, cancer status, smoking (never-smokers, >0 to <10, ≥10 cigarettes/day)
#
Similar findings among cancer cases vs controls