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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Int J Cardiol. 2018 Jun 3;281:166–171. doi: 10.1016/j.ijcard.2018.06.002

Figure 3:

Figure 3:

Left panels: LV Fibrosis. Representative histology images at 10× objective magnification of the LV stained with picrosirius red (upper panels) and the quantification of LV fibrosis staining (lower graph) in Sham+Vehicle, UNX+Vehicle and UNX+CD-NP rats. Values are mean 6 SEM. *P<0.05 vs Sham+Vehicle and P<0.05 vs UNX+Vehicle. Right panels: Diastolic Function. Effect of CD-NP treatment on preserving diastolic function in UNX+CD-NP rats compared to UNX+Vehicle rats. Values are mean 6 SEM. *P<0.05 vs Sham+Vehicle and P<0.05 vs UNX+Vehicle. The 37 amino acid structure of Cenderitide (CD-NP) is illustrated in the center bottom of the Figure 3. Cenderitide consists of the 22 amino acid structure of CNP (5 amino acid N-terminus in purple and 17 amino acid ring structure in red and yellow) together the 15 amino C-terminus of DNP in green. (Adapted from reference #41).