Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 7;15(4):943–953. doi: 10.1007/s13311-018-00674-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 2 — Molecular genetics of mitochondrial myopathy. A search of OMIM, ClinVar, and Mitomap from genes causing mitochondrial myopathy yielded 60 genes. Of these, 31 are mitochondrial genes, including 8 protein-encoding and 23 tRNA mutations. The remaining 29 genes are encoded by the nucleus and have a variety of functions, including subunits and assembly factors of the respiratory chain, mtDNA replication and maintenance, mitochondrial shape, mitochondrial translation, transport, proteases, lipid metabolism, and iron sulphur (Fe-S) cluster formation. Due to the speed at which needed genes are identified, this is likely to be an underestimate of causative genes.