Fig. 7.

Behavioral analysis of rats in different experimental groups 4 weeks after injection of AAV9 vectors. Motor performance was analyzed using the cylinder test (a, d), the rotarod test (b, e), and the open field test for locomotor activity (c, f). Measurements show significant reductions in motor performance in lesioned rats relative to controls (saline and empty vectors), which were significantly improved by treatment with candesartan or telmisartan. Data are means ± SEM. ^*p < 0.05 relative to saline-injected group; ^#p < 0.05 relative to the AAV9-Ф-injected group; ^&p < 0.05 relative to the group injected with AAV9 expressing human WT α-syn (a–c) or expressing human A53T mutated α-syn (d–f). One-way ANOVA followed by Holm–Sidak post hoc test. Abbreviations: α-syn A53T = A53T mutated alpha-synuclein; α-syn WT = wild-type alpha-synuclein; ANOVA = analysis of variance; CAND = candesartan; SEM = standard error of the mean; TELM = telmisartan; Ф = empty-null