Fig. 5.

Effect of lncRNA PVT1 on glioma growth in vivo. (A–C) The influence of lncRNA PVT1 on tumor size, volume, and weight of mice that were injected with transfected U251 cells was confirmed in tumor xenograft assay. ^*p < 0.05, ^**p < 0.01, ^#p < 0.05, ^##p < 0.01. (D) Effects of lncRNA PVT1 knockdown on miR-128-3p expression in glioma tissues of mice injected with U251 cells were examined by qRT-PCR. ^**p < 0.01, ^##p < 0.01. (E–G) The influence of lncRNA PVT1 on tumor size, volume, and weight of mice that were injected with transfected U87 cells was confirmed in tumor xenograft assay. *p < 0.05, ^**p < 0.01, ^#p < 0.05, ^##p < 0.01. (H) Effects of lncRNA PVT1 knockdown on miR-128-3p expression in glioma tissues of mice injected with U87 cells were determined by qRT-PCR. ^**p < 0.01, ^##p < 0.01