Fig. 9.

Effect of miR-128-3p/GREM1 axis on glioma growth in vivo. (A, E) The size of tumors in mice of the miR-128-3p mimic group was significantly smaller compared with the NC and mimic-NC groups. (B, C, F, G) The volumes and weight of tumors in the miR-128-3p mimic group were also remarkably decreased in contrast to those in the NC and mimic-NC groups. ^*p < 0.05, ^**p < 0.01, ^#p < 0.05, ^##p < 0.01. (D, H) QRT-PCR examined the impact of miR-128-3p on the expression of GREM1 in glioma tissues of mice. Compared with the NC group and the mimic-NC group, GREM1 expression was considerably downregulated after overexpression of miR-128-3p. ^**p < 0.01, ^##p < 0.01