Fig. 8.

ARG-1 immunolabeled MG/MΦ in the hippocampi of MyD88-inhibited and MyD88-deficient mice 3 days after SE. ARG-1-positive MG/MΦ in the CP group (A1–A3) and MIP group (B1–B3) at 3 days. (C1–C3) Higher magnification of the boxes in (B1–B3). Arrows indicate colocalization of ARG-1 and iba-1 immunoreactivity. (D) Comparison of the numbers of iba-1/ARG-1 double-positive cells in the DG, CA1, and CA3 between the CP and MIP groups (means ± SEM, n = 3). **p < 0.01 versus the CP group; ***p < 0.001 versus the CP group. Independent samples t tests were performed. (E) Stack scanning of an ARG-1-positive MG/MΦ in the hippocampus of an MyD88^−/− mouse showing colocalization of ARG-1 and iba-1 in the cytoplasm. Scale bars: (A1–B3) 100 μm; (C1–C3) 50 μm; (E) 12.5 μm