Table 4.
Dose of perindopril + atorvastatin combination by study and for the merged full analysis set
| CONFIDENCE II (N = 1253) |
PROTECT I (N = 988) |
STH I (N = 552) |
STH II (N = 379) |
Merged FAS (N = 3172) |
|
|---|---|---|---|---|---|
| Baseline perindopril dose, n (%) | |||||
| 2 mg | 219 (17.5) | 215 (21.8) | 49 (8.9) | 29 (7.7) | 512 (16.1) |
| 4 mg | 956 (76.3) | 688 (69.6) | 386 (69.6) | 270 (71.2) | 2300 (72.5) |
| 6 mg | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.3) | 1 (0.03) |
| 8 mg | 62 (4.9) | 58 (5.9) | 114 (20.7) | 75 (19.8) | 309 (9.7) |
| 16 mg | 0 (0.0) | 1 (0.1) | 0 (0.0) | 0 (0.0) | 1 (0.03) |
| Missing | 16 (1.3) | 26 (2.6) | 3 (0.5) | 4 (1.1) | 49 (1.5) |
| Baseline atorvastatin dose, n (%) | |||||
| 5 mg | 2 (0.2) | 3 (0.3) | 0 (0.0) | 6 (1.6) | 11 (0.3) |
| 10 mg | 343 (27.4) | 339 (34.3) | 147 (26.6) | 132 (34.8) | 961 (30.3) |
| 15 mg | 1 (0.1) | 1 (0.1) | 0 (0.0) | 1 (0.3) | 3 (0.1) |
| 20 mg | 339 (27.1) | 233 (23.6) | 170 (30.8) | 119 (31.4) | 861 (27.1) |
| 30 mg | 4 (0.3) | 1 (0.1) | 3 (0.5) | 4 (1.1) | 12 (0.4) |
| 40 mg | 176 (14.0) | 112 (11.3) | 174 (31.5) | 86 (22.7) | 548 (17.3) |
| > 40 to < 80 mg | 5 (0.4) | 0 (0.0) | 5 (0.9) | 6 (1.6) | 16 (0.5) |
| 80 mg | 39 (3.1) | 24 (2.4) | 38 (6.9) | 19 (5.0) | 120 (3.8) |
| > 80 mg | 0 (0.0) | 0 (0.0) | 3 (0.5) | 0 (0.0) | 3 (0.1) |
| Missing | 344 (27.5) | 275 (27.8) | 12 (2.2) | 6 (1.6) | 637 (20.1) |
| Dose of atorvastatin + perindopril, n (%) | |||||
| Remained on same dose until last available visit | 523 (41.7) | 320 (32.4) | 333 (60.3) | 204 (53.8) | 1380 (43.5) |
| Changed dose for at least one drug | 334 (26.7) | 368 (37.2) | 162 (29.3) | 145 (38.3) | 1009 (31.8) |
| At least one drug dose was missing | 396 (31.6) | 300 (30.4) | 57 (10.3) | 30 (7.9) | 783 (24.7) |
FAS full analysis set, STH Shake the Habit