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(A) Hematoxylin‐eosin–stained section reveals frequent enlarged or ballooned neurons that are immunoreactive for hyperphosphorylated Tau (inset; AT8). (B) Immunohistochemistry for hyperphosphorylated Tau reveals a characteristic astrocytic plaque in frontal cortex (AT8 immunohistochemistry). (C) Abundant cellular processes in white matter along with frequent oligodendroglial inclusions in the form of coiled bodies (inset; AT8 immunohistochemistry).
