Figure 1.

Western diet feeding leads to weight gain, insulin resistance and inflammation in wild type and Sirt3^−/− mice. Two month-old male wild type and Sirt3^−/− mice were fed standard diet (SD) or western diet (WD) for 4 months. (a) The mouse body weight gain was monitored during the course of feeding different diets. (b) Insulin, triglycerides and C-reactive protein (CRP) levels were measured in the plasma samples, using standard kits at the end of the study. Values are mean ± SE of 6 mice in each group. *P < 0.01; **P < 0.001, compared to wild type mice on standard diet. ^#P < 0.001 vs Sirt3^−/− mice on standard diet.