Table 4.

Genetic correlation between CHD and stroke traits with cIMT and plaque, and cIMT with plaque using LD score and meta-GWAS

Cardiovascular disease trait	Subclinical atherosclerosis trait	Genetic correlation	SE	z	p
CHDa	cIMT	0.20	0.05	4.1114	4 × 10−5
Any stroke	cIMT	0.30	0.07	4.2301	2.3 × 10−5
Ischemic strokeb	cIMT	0.31	0.07	4.646	3.4 × 10−6
Cardio-embolic strokeb	cIMT	0.10	0.09	1.0729	0.28
Small vessel disease strokeb	cIMT	0.33	0.18	1.8728	0.06
CHDa	Carotid plaque	0.52	0.08	6.4263	1.3 × 10−10
Any strokeb	Carotid plaque	0.28	0.10	2.7097	0.007
Ischemic strokeb	Carotid plaque	0.27	0.10	2.6578	0.008
Cardio-embolic strokeb	Carotid plaque	0.06	0.14	0.4684	0.64
Small vessel disease strokeb	Carotid plaque	−0.03	0.24	−0.1344	0.89
Plaque	cIMT	0.40	0.10	3.9667	7.3 × 10−5

^aCARDIoGRAMPlusC4D

^bMEGASTROKE consortium. Unable to estimate the genetic correlations with large vessel disease