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. 2018 Dec 3;8:17544. doi: 10.1038/s41598-018-35978-0

Figure 3.

Figure 3

Midostaurin Reduces FOXP3 Expression and T cell cytokines. (A) Effect of various inhibitors on FOXP3 mRNA expression in healthy PBMCs (N = 5, p < 0.05). (B) Cytokine levels in picograms/ml were measured in cell treated supernatants and normalized to IL-2/IL-7 treated group (n = 3 p < 0.05). (C) PBMCs were treated with four different kinase inhibitors for 72 hours and showed a 20% reduction in viability for both healthy (N = 3) and AML (N = 5) groups. MV4-11 cells were used as a positive control for kinase inhibitors and showed over 50% reduction in viability (N = 8).