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. 2018 Dec 3;8:17544. doi: 10.1038/s41598-018-35978-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Midostaurin reduces Tregs in AML cells. (A) Representative contour plots of T cell populations from patients with AML treated with midostaurin. (B) In vitro PBMCs were treated with one of the four kinase inhibitors and normalized to IL-2/IL-7 control population percentages (n = 4, p < 0.05). (C) FOXP3 mRNA expression in AML PBMCs (n = 4) treated ex vivo with 1uM of midostaurin. (D) Cytokine levels in picograms/ml were measured in AML cells treated supernatants and normalized to IL-2/IL-7 treated group (N = 5).