Figure 5.

rBCG-Japan/PhoPR Reduces the Lung Pathology of Guinea Pigs Infected with Mtb

Five guinea pigs from the long-term survival experiment were chosen for histological analysis. These include one guinea pig from the PBS group (A), the pME group (B), and the PhoPR group (C) that reached the humane endpoint at weeks 25, 27, and 39, respectively. The pME (B) and PhoPR (C) guinea pigs represent the sixth animal to be euthanized from each group (median). The sole survivor from the pME group (D) and one randomly chosen survivor from the PhoPR group (E) were also included. For each guinea pig, sections of caudal and cranial lobes of the left lungs were analyzed by H&E staining.